Dual-functional lipid-like nanoparticles for delivery of mRNA and MRI contrast agents.

@article{Luo2017DualfunctionalLN,
  title={Dual-functional lipid-like nanoparticles for delivery of mRNA and MRI contrast agents.},
  author={X Luo and B. Li and Xiuying Zhang and W Zhao and Anna Bratasz and Binbin Deng and David W. McComb and Y Dong},
  journal={Nanoscale},
  year={2017},
  volume={9 4},
  pages={
          1575-1579
        }
}
Multi-functional nanomaterials possess unique properties, facilitating both therapeutic and diagnostic applications among others. Herein, we developed dual-functional lipid-like nanoparticles for simultaneous delivery of mRNA and magnetic resonance imaging (MRI) contrast agents in order to express functional proteins and provide real-time visualization. TT3-Gd18 LLNs were identified as a lead formulation, which was able to encapsulate 91% of mRNA and 74% of Gd. This formulation showed a… Expand
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