Dual-functional biomimetic materials: nonfouling poly(carboxybetaine) with active functional groups for protein immobilization.

@article{Zhang2006DualfunctionalBM,
  title={Dual-functional biomimetic materials: nonfouling poly(carboxybetaine) with active functional groups for protein immobilization.},
  author={Zheng Zhang and Shengfu Chen and Shaoyi Jiang},
  journal={Biomacromolecules},
  year={2006},
  volume={7 12},
  pages={3311-5}
}
We introduce a dual-functional biocompatible material based on zwitterionic poly(carboxybetaine methacrylate) (polyCBMA), which not only highly resists protein adsorption/cell adhesion, but also has abundant functional groups convenient for the immobilization of biological ligands, such as proteins. The dual-functional properties are unique to carboxybetaine moieties and are not found in other nonfouling moieties such as ethylene glycol, phosphobetaine, and sulfobetaine. The unique properties… CONTINUE READING
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