Dual function of the selenoprotein PHGPx during sperm maturation.


The selenoprotein phospholipid hydroperoxide glutathione peroxidase (PHGPx) changes its physical characteristics and biological functions during sperm maturation. PHGPx exists as a soluble peroxidase in spermatids but persists in mature spermatozoa as an enzymatically inactive, oxidatively cross-linked, insoluble protein. In the midpiece of mature… (More)


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@article{Ursini1999DualFO, title={Dual function of the selenoprotein PHGPx during sperm maturation.}, author={Francesca Ursini and S. Heim and Marla C. Kiess and Maria Ida Maiorino and Anna Maria Donadoni Roveri and Jeroen Wissing and Leopold Floh{\'e}}, journal={Science}, year={1999}, volume={285 5432}, pages={1393-6} }