Dual function of polycomb group proteins in differentiated murine T helper (CD4+) cells

@inproceedings{Jacob2011DualFO,
  title={Dual function of polycomb group proteins in differentiated murine T helper (CD4+) cells},
  author={Eyal Jacob and Reut Hod-Dvorai and Or Lea Ben-Mordechai and Yulia Boyko and Orly Avni},
  booktitle={Journal of molecular signaling},
  year={2011}
}
BACKGROUND Following antigen recognition, naive T helper (Th; CD4+) cells can differentiate toward one of several effector lineages such as Th1 and Th2; each expressing distinctive transcriptional profiles of cytokine genes. These cytokines eventually instruct the strategy of the immune response. In our search for factors that propagate the transcriptional programs of differentiated Th cells, we previously found that Polycomb group (PcG) proteins, which are known as epigenetic regulators that… CONTINUE READING

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