Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway.

@article{Maloverjan2010DualFO,
  title={Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway.},
  author={Alla Maloverjan and Marko Piirsoo and Lagle Kasak and Lauri Peil and Torben \Osterlund and Priit Kogerman},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 39},
  pages={30079-90}
}
The Sonic hedgehog (Shh) signaling pathway controls a variety of developmental processes and is implicated in tissue homeostasis maintenance and neurogenesis in adults. Recently, we identified Ulk3 as an active kinase able to positively regulate Gli proteins, mediators of the Shh signaling in mammals. Here, we provide several lines of evidence that Ulk3 participates in the transduction of the Shh signal also independently of its kinase activity. We demonstrate that Ulk3 through its kinase… CONTINUE READING
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