Dual function of Src in the maintenance of adherens junctions during tracheal epithelial morphogenesis.

@article{Shindo2008DualFO,
  title={Dual function of Src in the maintenance of adherens junctions during tracheal epithelial morphogenesis.},
  author={Masayo Shindo and Housei Wada and Masako Kaido and Minoru Tateno and Toshiro Aigaki and Leo Tsuda and Shigeo Hayashi},
  journal={Development},
  year={2008},
  volume={135 7},
  pages={1355-64}
}
The downregulation of E-cadherin by Src promotes epithelial to mesenchymal transition and tumorigenesis. However, a simple loss of cell adhesion is not sufficient to explain the diverse developmental roles of Src and metastatic behavior of viral Src-transformed cells. Here, we studied the functions of endogenous and activated forms of Drosophila Src in the context of tracheal epithelial development, during which extensive remodeling of adherens junctions takes place. We show that Src42A is… CONTINUE READING

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