Dual function of Slit2 in repulsion and enhanced migration of trunk, but not vagal, neural crest cells

@article{Bellard2003DualFO,
  title={Dual function of Slit2 in repulsion and enhanced migration of trunk, but not vagal, neural crest cells},
  author={Maria Elena De Bellard and Yi Rao and Marianne Bronner-Fraser},
  journal={The Journal of Cell Biology},
  year={2003},
  volume={162},
  pages={269 - 279}
}
Neural crest precursors to the autonomic nervous system form different derivatives depending upon their axial level of origin; for example, vagal, but not trunk, neural crest cells form the enteric ganglia of the gut. Here, we show that Slit2 is expressed at the entrance of the gut, which is selectively invaded by vagal, but not trunk, neural crest. Accordingly, only trunk neural crest cells express Robo receptors. In vivo and in vitro experiments demonstrate that trunk, not vagal, crest cells… CONTINUE READING

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