Dual effects of rifampin on the pharmacokinetics of atrasentan.

@article{Xiong2007DualEO,
  title={Dual effects of rifampin on the pharmacokinetics of atrasentan.},
  author={Hao Xiong and Robert A. Carr and Charles S. Locke and David A. Katz and Ramanuj Achari and Thao T Doan and Perry Wang and James R Jankowski and Darryl J. Sleep},
  journal={Journal of clinical pharmacology},
  year={2007},
  volume={47 4},
  pages={423-9}
}
The effect of rifampin, a cytochrome P450 3A4 inducer, on the pharmacokinetics of atrasentan was assessed in 12 healthy male subjects in an open-label study. Single doses of atrasentan 10 mg were administered orally on days 1 and 12. Rifampin 600 mg was given once daily from days 4 through 14. On day 12, atrasentan and rifampin were administered simultaneously. Blood samples were collected before and during 72 hours after each atrasentan dose. On average, rifampin increased atrasentan peak… CONTINUE READING

From This Paper

Topics from this paper.
12 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

Similar Papers

Loading similar papers…