Dual effects of nordidemnin on WRK1 cells: inhibition of phosphoinositide metabolism and cell proliferation.

@article{Dominice1994DualEO,
  title={Dual effects of nordidemnin on WRK1 cells: inhibition of phosphoinositide metabolism and cell proliferation.},
  author={Carole Dominice and Myl{\`e}ne Dufour and N. Navarro Pati{\~n}o and Olivier J Manzoni and Eric Grazzini and Patrick Jouin and Gilles Guillon},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1994},
  volume={271 1},
  pages={
          107-17
        }
}
Nordidemnin (NorD), a cyclodepsipeptide isolated from marine invertebrates, exhibits antiproliferative and antitumoral properties identical to didemnin B on many cell lines. On WRK1 cells, a rat mammary tumor cell line, NorD considerably reduced the vasopressin-stimulated accumulation of inositol phosphates. This effect was more pronounced on dividing cells and of weak amplitude on quiescent ones. It was observed with nanomolar concentrations of NorD and became significative after 3 hr of… CONTINUE READING