Dual effects of nicotine on oxidative stress and neuroprotection in PC12 cells.

@article{Guan2003DualEO,
  title={Dual effects of nicotine on oxidative stress and neuroprotection in PC12 cells.},
  author={Zhi-Zhong Guan and Wen-feng Yu and A. Nordberg},
  journal={Neurochemistry international},
  year={2003},
  volume={43 3},
  pages={243-9}
}
In order to identify the properties of nicotine in relation to oxidative stress or neuroprotection, differentiated PC12 cells were treated with nicotine, beta-amyloid peptide (Abeta(25-35)), free radical inducer and antioxidant by a separate addition or a combination way. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction, lipid peroxidation, [3H]epibatidine binding sites for nicotinic receptor and [3H]quinuclidinyl benzilate (QNB) for muscarinic receptor have been… CONTINUE READING

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