Dual effects of hepatitis B virus X protein on the regulation of cell-cycle control depending on the status of cellular p53.

@article{Ahn2002DualEO,
  title={Dual effects of hepatitis B virus X protein on the regulation of cell-cycle control depending on the status of cellular p53.},
  author={Ji Young Ahn and Eun Young Jung and Hyun Jin Kwun and Chang-woo Lee and Young Chul Sung and Kyung Lib Jang},
  journal={The Journal of general virology},
  year={2002},
  volume={83 Pt 11},
  pages={
          2765-72
        }
}
Despite the extensive studies on the roles of hepatitis B virus (HBV) X protein (HBx) in the development of hepatocellular carcinomas (HCCs), the mechanisms by which HBx contributes to HCC remain controversial. In this study, the effect of HBx on the G(1)-S checkpoint control depending on the status of p53 was compared. Transcription of p21(waf1/cip1) was activated by HBx in the presence of functional p53 in a dose-dependent manner. However, it was repressed by HBx when p53 was absent or… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 30 REFERENCES