Dual effects of calcium on ATP-sensitive potassium channels of frog skeletal muscle.

@article{KrippeitDrews1992DualEO,
  title={Dual effects of calcium on ATP-sensitive potassium channels of frog skeletal muscle.},
  author={Peter Krippeit-Drews and U. L{\"o}nnendonker},
  journal={Biochimica et biophysica acta},
  year={1992},
  volume={1108 1},
  pages={119-22}
}
The block of ATP-sensitive K+ channels by ATP were studied in inside-out patches of frog toe muscles. Seal formation within Ca(2+)-free Ringer induces many open channels which can be irreversibly blocked by subsequent addition of Ca2+. However, such Ca(2+)-blocked and ATP-blocked channels can be influenced by the addition of ATP and Ca2+: the block by ATP is partially but irreversibly cancelled.