Dual effects of ascorbate on serotonin and spiperone binding in rat cortical membranes.

Abstract

Ascorbate-induced lipid peroxidation, as measured by malonyldialdehyde (MDA) production, caused irreversible decreases in Bmax of both [3H]5-HT and [3H]spiperone binding. CaCl2 (4 mM) inhibited ascorbate-induced MDA formation at ascorbate concentrations greater than 0.57 mM, but not at less than or equal to 0.57 mM. Under the standard assay conditions (5.7… (More)

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@article{MuakkassahKelly1983DualEO, title={Dual effects of ascorbate on serotonin and spiperone binding in rat cortical membranes.}, author={S. F. Muakkassah-Kelly and J W Andresen and J. C. Shih and Paul Hochstein}, journal={Journal of neurochemistry}, year={1983}, volume={41 5}, pages={1429-39} }