Dual effects of TGF-β on ERα-mediated estrogenic transcriptional activity in breast cancer

Abstract

TGF-β resistance often develops in breast cancer cells that in turn overproduce this cytokine to create a local immunosuppressive environment that fosters tumor growth and exacerbates the invasive and metastatic behavior of the tumor cells themselves. Smads-mediated cross-talk with the estrogen receptor has been implied to play an important role in… (More)
DOI: 10.1186/1476-4598-8-111

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