Dual effects of D-amphetamine on dopamine neurons mediated by dopamine and nondopamine receptors.

  title={Dual effects of D-amphetamine on dopamine neurons mediated by dopamine and nondopamine receptors.},
  author={W X Shi and C L Pun and Xian-man Zhang and Michelle D Jones and Bejamin S Bunney},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={20 9},
By increasing dopamine (DA) release and activating feedback mechanisms, amphetamine and related psychostimulants are known to inhibit DA cell firing. Here, we report that D-amphetamine also has an excitatory effect on DA cells, which under control conditions, is masked by the inhibitory effect of D-amphetamine and is revealed when D2-like receptors are blocked. Thus, using in vivo single-unit recording in rats, we found that the selective D2 antagonist raclopride not only blocked the inhibition… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
76 Citations
38 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 76 extracted citations


Publications referenced by this paper.
Showing 1-10 of 38 references

Adrenergic a1mediated increase in bursting of DA neurons: role of glutamate

  • Zhang X-X, Pun C-L, BS Bunney, Shi W-X
  • Soc Neurosci Abstr
  • 1999

Opposite effects of psychostimulants on DA neurons mediated by DA and non-DA receptors

  • WX Shi, C-L Pun, X-X Zhang, PL Smith, MD Jones
  • Soc Neurosci Abstr
  • 1999
2 Excerpts

d-Amphetamine-induced excitation of midbrain DA neurons: an effect mediated by a1 receptors

  • WX Shi, CL Pun, M Jones, BS Bunney
  • Soc Neurosci Abstr
  • 1998
1 Excerpt

An a1-mediated adrenergic excitation of midbrain dopamine neurons: activated by d-amphetamine and blocked by antipsychotic drugs

  • WX Shi, CL Pun, M Jones, BS Bunney
  • American College of Neuropsychopharmacology 36th…
  • 1997
3 Excerpts

Similar Papers

Loading similar papers…