Dual effects of D-amphetamine on dopamine neurons mediated by dopamine and nondopamine receptors.

@article{Shi2000DualEO,
  title={Dual effects of D-amphetamine on dopamine neurons mediated by dopamine and nondopamine receptors.},
  author={W X Shi and C L Pun and Xian-man Zhang and Michelle D Jones and Bejamin S Bunney},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2000},
  volume={20 9},
  pages={3504-11}
}
By increasing dopamine (DA) release and activating feedback mechanisms, amphetamine and related psychostimulants are known to inhibit DA cell firing. Here, we report that D-amphetamine also has an excitatory effect on DA cells, which under control conditions, is masked by the inhibitory effect of D-amphetamine and is revealed when D2-like receptors are blocked. Thus, using in vivo single-unit recording in rats, we found that the selective D2 antagonist raclopride not only blocked the inhibition… CONTINUE READING
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Adrenergic a1mediated increase in bursting of DA neurons: role of glutamate

  • Zhang X-X, Pun C-L, BS Bunney, Shi W-X
  • Soc Neurosci Abstr
  • 1999

Opposite effects of psychostimulants on DA neurons mediated by DA and non-DA receptors

  • WX Shi, C-L Pun, X-X Zhang, PL Smith, MD Jones
  • Soc Neurosci Abstr
  • 1999
2 Excerpts

d-Amphetamine-induced excitation of midbrain DA neurons: an effect mediated by a1 receptors

  • WX Shi, CL Pun, M Jones, BS Bunney
  • Soc Neurosci Abstr
  • 1998
1 Excerpt

An a1-mediated adrenergic excitation of midbrain dopamine neurons: activated by d-amphetamine and blocked by antipsychotic drugs

  • WX Shi, CL Pun, M Jones, BS Bunney
  • American College of Neuropsychopharmacology 36th…
  • 1997
3 Excerpts

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