Dual effect of trimebutine on contractility of the guinea pig ileum via the opioid receptors.

@article{Taniyama1991DualEO,
  title={Dual effect of trimebutine on contractility of the guinea pig ileum via the opioid receptors.},
  author={Kohtaro Taniyama and Isamu Sano and S. Nakayama and Shogo Matsuyama and K. Takeda and Chika Yoshihara and Chikako Tanaka},
  journal={Gastroenterology},
  year={1991},
  volume={101 6},
  pages={
          1579-87
        }
}
Preparations of longitudinal muscle attached to myenteric plexus from guinea pig ileum were used to observe the effect of trimebutine on intestinal motility. Electrical stimulation at 0.2 Hz and 5 Hz produced contraction mediated by the release of acetylcholine in the preparations. The response to low-frequency stimulation (0.2 Hz) was inhibited by trimebutine (10(-8)-10(-5) mol/L), and the response to high-frequency stimulation (5 Hz) was enhanced by the drug at low concentrations (10(-8)-10… Expand
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