Dual effect of the SR proteins ASF/SF2, SC35 and 9G8 on HIV-1 RNA splicing and virion production

@article{Jacquenet2005DualEO,
  title={Dual effect of the SR proteins ASF/SF2, SC35 and 9G8 on HIV-1 RNA splicing and virion production},
  author={Sandrine Jacquenet and Didier D{\'e}cimo and Delphine M. Muriaux and J L Darlix},
  journal={Retrovirology},
  year={2005},
  volume={2},
  pages={33 - 33}
}
In HIV-1 infected cells transcription of the integrated provirus generates the single full length 9 kb viral RNA, a major fraction of which is spliced to produce the single-spliced 4 kb RNAs and the multiple-spliced 2 kb RNAs. These spliced RNAs are the messengers for the Env glycoproteins and the viral regulatory factors. The cellular SR and hnRNP proteins were shown in vitro to control alternative splicing by binding cis-regulatory elements on the viral RNA. To better understand in vivo the… CONTINUE READING

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