Dual effect of serotonin on growth of bovine pulmonary artery smooth muscle cells in culture.

@article{Lee1991DualEO,
  title={Dual effect of serotonin on growth of bovine pulmonary artery smooth muscle cells in culture.},
  author={S L Lee and Warner W Wang and Bryan Moore and Barry L. Fanburg},
  journal={Circulation research},
  year={1991},
  volume={68 5},
  pages={1362-8}
}
We have previously reported that serotonin (5-hydroxytryptamine [5HT]) alters cultured bovine pulmonary artery smooth muscle cell (SMC) configuration through two different regulatory mechanisms. We now report that 5HT also regulates SMC growth through these same two mechanisms--a stimulatory event initiated intracellularly and inhibition of growth resulting from a cell surface action. 5HT (1 microM) plus 0.1 mM iproniazid (a 5HT metabolic inhibitor) produced a severalfold stimulation of DNA… CONTINUE READING
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