Dual effect of interleukin 4 on HIV-1 expression: implications for viral phenotypic switch and disease progression.

@article{Valentn1998DualEO,
  title={Dual effect of interleukin 4 on HIV-1 expression: implications for viral phenotypic switch and disease progression.},
  author={Antonio Valent{\'i}n and Wuyuan Lu and Margherita Rosati and Reto Schneider and Jan Albert and Anders Karlsson and George N Pavlakis},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 15},
  pages={8886-91}
}
We report that interleukin 4 (IL-4) inhibits the propagation of non-syncytia-inducing and increases the propagation of syncytia-inducing HIV-1 isolates by two mechanisms. It differentially regulates the two major HIV-1 coreceptors, CCR5 and CXCR4, in human peripheral blood mononuclear cells, increasing CXCR4 and decreasing CCR5 expression in primary CD4(+) T-lymphocytes. In addition, IL-4 stimulates the expression of all HIV-1 isolates via a transcriptional activation mechanism. The combination… CONTINUE READING
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