Dual effect of insulin-like growth factor on the apical 70-pS K channel in the thick ascending limb of rat kidney.

@article{Wei2004DualEO,
  title={Dual effect of insulin-like growth factor on the apical 70-pS K channel in the thick ascending limb of rat kidney.},
  author={Yuan Wei and Yu-Jung Chen and Dimin Li and Ruimin Gu and Wen-hui Wang},
  journal={American journal of physiology. Cell physiology},
  year={2004},
  volume={286 6},
  pages={
          C1258-63
        }
}
We used the patch-clamp technique to study the effect of insulin-like growth factor I (IGF-I) on the apical 70-pS K channel in the isolated thick ascending limb (TAL) of the rat kidney. The isolated TAL was cut open to gain access to the apical membrane. Addition of 25 nM IGF-I stimulates the apical 70-pS K channel and increases channel activity, defined by the product of channel open probability and channel number, from 0.31 to 1.21. The stimulatory effect of IGF-I is not mediated by nitric… CONTINUE READING

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