Dual effect of erbB-2 depletion on the regulation of DNA repair and cell cycle mechanisms in non-small cell lung cancer cells

Abstract

Overexpression of the erbB-2 tyrosine kinase receptor, p185erbB-2, is a common alteration in non-small cell lung cancer (NSCLC) and has been associated with poor prognosis and a tumor drug resistance phenotype. In this study, we have examined the consequences of erbB-2 depletion on DNA repair, cell cycle, and apoptosis using a panel of NSCLC cell lines… (More)
DOI: 10.1038/sj.onc.1202246

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@article{You1998DualEO, title={Dual effect of erbB-2 depletion on the regulation of DNA repair and cell cycle mechanisms in non-small cell lung cancer cells}, author={Xiao-Li You and Lily Yen and Nie Zeng-Rong and Ala-Eddin Al Moustafa and Moulay A. Alaoui-Jamali}, journal={Oncogene}, year={1998}, volume={17}, pages={3177-3186} }