Dual effect of Platelet Factor 4 on the activities of Factor Xa.

Abstract

Platelet Factor 4 (PF4) prevents inhibition of blood coagulation proteases by heparin via formation of a putative enzyme-PF4 complex. To investigate the contribution of the latter, the activity of factor Xa (fXa) was determined in chromogenic assays measuring hydrolysis of a peptide substrate S2765 or cleavage of the macromolecular substrate prothrombin in… (More)
DOI: 10.1016/j.bbrc.2009.01.016

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@article{Fiore2009DualEO, title={Dual effect of Platelet Factor 4 on the activities of Factor Xa.}, author={Martine M Fiore and Ian J. Mackie}, journal={Biochemical and biophysical research communications}, year={2009}, volume={379 4}, pages={1072-5} }