Dual effect of PEG-PE micelle over the oligomerization and fibrillation of human islet amyloid polypeptide

@inproceedings{Fang2018DualEO,
  title={Dual effect of PEG-PE micelle over the oligomerization and fibrillation of human islet amyloid polypeptide},
  author={Xiaocui Fang and Maryam Yousaf and Qun-xing Huang and Yanlian Yang and Chen Wang},
  booktitle={Scientific Reports},
  year={2018}
}
The oligomerization and fibrillation of human islet amyloid polypeptide (hIAPP) play a central role in the pathogenesis of type 2 diabetes. Strategies for remodelling the formation of hIAPP oligomers and fibrils have promising application potential in type 2 diabetes therapy. Herein, we demonstrated that PEG-PE micelle could inhibit hIAPP oligomerization… CONTINUE READING