Dual effect of CTCF loss on neuroprogenitor differentiation and survival.

  title={Dual effect of CTCF loss on neuroprogenitor differentiation and survival.},
  author={Leslie A. Watson and Xu Wang and Adrienne Elbert and Kristin D. Kernohan and Niels Galjart and Nathalie G B{\'e}rub{\'e}},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={34 8},
An increasing number of proteins involved in genome organization have been implicated in neurodevelopmental disorders, highlighting the importance of chromatin architecture in the developing CNS. The CCCTC-binding factor (CTCF) is a zinc finger DNA binding protein involved in higher-order chromatin organization, and mutations in the human CTCF gene cause an intellectual disability syndrome associated with microcephaly. However, information on CTCF function in vivo in the developing brain is… CONTINUE READING
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