Dual drugs (microRNA-34a and paclitaxel)-loaded functional solid lipid nanoparticles for synergistic cancer cell suppression.

@article{Shi2014DualD,
  title={Dual drugs (microRNA-34a and paclitaxel)-loaded functional solid lipid nanoparticles for synergistic cancer cell suppression.},
  author={Sanjun Shi and Lu Han and Li Deng and Yanling Zhang and Hongxin Shen and Tao Gong and Zhirong Zhang and Xun Sun},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2014},
  volume={194},
  pages={
          228-37
        }
}
A co-delivery system that can transport cancer related microRNAs and chemotherapeutics to their distinct targets in the tumors is an attractive strategy to eliminate tumor relapse in lung cancer therapy. In this study, we developed a dual-drug delivery system for an endogenous microRNA (miR-34a) and paclitaxel (PTX) for synergistic cancer therapy. PTX (a meiotic inhibitor) and miR-34a were loaded into cationic solid lipid nanoparticles (miSLNs-34a/PTX) which were used to treat murine B16F10… CONTINUE READING
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