Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders

  title={Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders},
  author={Kristi M. Anderson and Katherine E. Olson and Katherine A. Estes and Ken Flanagan and Howard E. Gendelman and R. Lee Mosley},
  booktitle={Translational Neurodegeneration},
Inappropriate T cell responses in the central nervous system (CNS) affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include, but are not limited to, multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer’s disease and Parkinson’s disease. On the one hand immune responses can exacerbate neurotoxic responses; while on the other hand, they can lead to neuroprotective outcomes. The temporal and spatial mechanisms by which these immune… CONTINUE READING
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