Dual-delivery of VEGF and PDGF by double-layered electrospun membranes for blood vessel regeneration.

  title={Dual-delivery of VEGF and PDGF by double-layered electrospun membranes for blood vessel regeneration.},
  author={Hong Zhang and Xiaoling Jia and Fengxuan Han and Jin Zhao and Yunhui Zhao and Yubo Fan and Xiaoyan Yuan},
  volume={34 9},
Tissue engineering of small-diameter blood vessels is still challenging because of restenosis and burst. To prevent thrombosis, rapid endothelialization along the lumen of grafts is intended, followed by proliferation of vascular smooth muscle cells (VSMCs) around the exterior for compliance. To this goal, two modified coaxial electrospinning techniques were developed to encapsulate vascular endothelial growth factor (VEGF) and platelet-derived growth factor-bb (PDGF), respectively, to regulate… CONTINUE READING
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