Dual delivery of VEGF and ANG-1 in ischemic hearts using an injectable hydrogel.

@article{Rufaihah2017DualDO,
  title={Dual delivery of VEGF and ANG-1 in ischemic hearts using an injectable hydrogel.},
  author={Abdul Jalil Rufaihah and Nurul Azizah Binte Johari and Srirangam Ramanujam Vaibavi and Marian Plotkin and Do Thi Di Thien and Theodoros Kofidis and Dror Seliktar},
  journal={Acta biomaterialia},
  year={2017},
  volume={48},
  pages={58-67}
}
Acute myocardial infarction (MI) caused by ischemia is the most common cause of cardiac dysfunction. While growth factor therapy is promising, the retention in the highly vascularized myocardium is limited and prevents sustained activation needed for adequate cellular responses. Here, we demonstrated the use of polyethylene glycol-fibrinogen (PF) hydrogels for sustained dual delivery of vascular endothelial growth factor (VEGF) and angiopoietin-1 (ANG-1) to enhance myocardial repair and… CONTINUE READING