Dual control of neurogenesis by PC3 through cell cycle inhibition and induction of Math1.

@article{Canzoniere2004DualCO,
  title={Dual control of neurogenesis by PC3 through cell cycle inhibition and induction of Math1.},
  author={Daniela Canzoniere and Stefano Farioli-Vecchioli and Filippo Conti and Maria Teresa Ciotti and Ada Maria Tata and Gabriella Augusti-Tocco and Elisabetta Mattei and Madepalli K Lakshmana and Valery Krizhanovsky and Steven A. Reeves and Roberto Giovannoni and Francesca Castano and Antonio Servadio and Nissim Ben-Arie and Felice Tirone},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2004},
  volume={24 13},
  pages={3355-69}
}
Growing evidence indicates that cell cycle arrest and neurogenesis are highly coordinated and interactive processes, governed by cell cycle genes and neural transcription factors. The gene PC3 (Tis21/BTG2) is expressed in the neuroblast throughout the neural tube and inhibits cell cycle progression at the G1 checkpoint by repressing cyclin D1 transcription. We generated inducible mouse models in which the expression of PC3 was upregulated in neuronal precursors of the neural tube and of the… CONTINUE READING

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