Dual control of muscle cell survival by distinct growth factor-regulated signaling pathways.

@article{Lawlor2000DualCO,
  title={Dual control of muscle cell survival by distinct growth factor-regulated signaling pathways.},
  author={Margaret A. Lawlor and Xin-hua Feng and D R Everding and Kerry A Sieger and Claire E H Stewart and Peter Rotwein},
  journal={Molecular and cellular biology},
  year={2000},
  volume={20 9},
  pages={3256-65}
}
In addition to their ability to stimulate cell proliferation, polypeptide growth factors are able to maintain cell survival under conditions that otherwise lead to apoptotic death. Growth factors control cell viability through regulation of critical intracellular signal transduction pathways. We previously characterized C2 muscle cell lines that lacked endogenous expression of insulin-like growth factor II (IGF-II). These cells did not differentiate but underwent apoptotic death in low-serum… CONTINUE READING
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