Dual contrast enhanced cardiac MRI using manganese and gadolinium in patients with severe ischemic cardiomyopathy detects the peri-infarct region (PIR)

@inproceedings{Matsuura2014DualCE,
  title={Dual contrast enhanced cardiac MRI using manganese and gadolinium in patients with severe ischemic cardiomyopathy detects the peri-infarct region (PIR)},
  author={Yuka Matsuura and Rajesh C. Dash and Paul J. Kim and Hadas Shiran and Aparna Bhagavat and Phillip P Harnish and Michael V. McConnell and Phillip C Yang},
  year={2014}
}
Background Delayed Enhanced MRI (DEMRI) with gadolinium (Gd) is used as gold standard for diagnosis of myocardial infarction. However, the non-specific property of Gd overestimates the infarct size. Conversely, manganese (Mn2+) enters only the live, active cardiomyocytes via L-type Ca2+ channels. From our earlier work in animal MI models, manganese-enhanced… CONTINUE READING