Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct.

@article{Nahrendorf2007DualCO,
  title={Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct.},
  author={Matthias Nahrendorf and David E. Sosnovik and Peter Waterman and Filip K Swirski and Ashvin N Pande and Elena Aikawa and Jose-Luiz Figueiredo and Mikael J Pittet and Ralph Weissleder},
  journal={Circulation research},
  year={2007},
  volume={100 8},
  pages={1218-25}
}
Inflammatory responses after myocardial infarction profoundly impact tissue repair. Yet, efficient tools to serially and noninvasively assess cellular and molecular functions in postinfarct inflammation are lacking. Here we use multichannel fluorescent molecular tomography (FMT) for spatiotemporal resolution of phagocytic and proteolytic activities mediated by macrophages and neutrophils in murine infarcts. We performed FMT imaging to compare the course of efficient and impaired healing in wild… CONTINUE READING