Dual blockade of the renin-angiotensin-aldosterone system in diabetic nephropathy: the role of aldosterone.

@article{Schjoedt2005DualBO,
  title={Dual blockade of the renin-angiotensin-aldosterone system in diabetic nephropathy: the role of aldosterone.},
  author={Katrine Jordan Schjoedt and Lars Bo Jacobsen and Kasper Rossing and Frans Boomsma and H. H. Parving},
  journal={Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme},
  year={2005},
  volume={37 Suppl 1},
  pages={
          4-8
        }
}
Dual blockade of the renin-angiotensin-aldosterone system (RAAS) with both ACE inhibitors and angiotensin II receptor-blockers has been shown to reduce both albuminuria and blood pressure compared to either monotherapy. The mechanisms behind these beneficial effects are not known, and we hypothesized that the effect of dual RAAS blockade may be due to a more complete suppression of circulating aldosterone. We performed a combined analysis on three randomized, double-masked, cross-over trials… CONTINUE READING

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