Dual blockade of angiotensin II with enalapril and losartan reduces proteinuria in hypertensive patients with type 2 diabetes.

@article{Igarashi2006DualBO,
  title={Dual blockade of angiotensin II with enalapril and losartan reduces proteinuria in hypertensive patients with type 2 diabetes.},
  author={Masahiko Igarashi and Akihiko Hirata and Yuko Kadomoto and Makoto Tominaga},
  journal={Endocrine journal},
  year={2006},
  volume={53 4},
  pages={493-501}
}
In this study we evaluated the effect of a dual blockade with enalapril and losartan on the reduction of overt macroproteinuria and its potential mechanism(s) in hypertensive patients with type 2 diabetes. Twenty-six hypertensive patients with type 2 diabetes at the baseline were administered 5 mg of enalapril once daily for 12 weeks. At the beginning of the study, the subjects were assigned to receive an add-on of 50 mg of losartan once daily or 5 mg of enalapril once daily for another 12… CONTINUE READING

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