Dual association by TFAP2A during activation of the p21cip/CDKN1A promoter.

@article{Scibetta2010DualAB,
  title={Dual association by TFAP2A during activation of the p21cip/CDKN1A promoter.},
  author={Angelo Giuseppe Scibetta and Ping-Pui Wong and K. V. Chan and Monica Canosa and Helen C. Hurst},
  journal={Cell cycle},
  year={2010},
  volume={9 22},
  pages={4525-32}
}
The cyclin-dependent kinase inhibitor p21cip/CDKN1A is induced to promote growth arrest in response to a variety of stimuli in normal cells and loss of correct regulation of this gene is frequently observed in cancer. In particular, the upregulation of CDKN1A by p53 is considered to be a central mechanism of tumour suppression. Other transcription factors with tumour suppressor activity can also regulate CDKN1A, including the developmentally regulated factor, TFAP2A. Here we identify a novel AP… CONTINUE READING

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