Dual anti-oxidant and anti-inflammatory actions of the electrophilic cyclooxygenase-2-derived 17-oxo-DHA in lipopolysaccharide- and cigarette smoke-induced inflammation.

@article{Cipollina2014DualAA,
  title={Dual anti-oxidant and anti-inflammatory actions of the electrophilic cyclooxygenase-2-derived 17-oxo-DHA in lipopolysaccharide- and cigarette smoke-induced inflammation.},
  author={Chiara Cipollina and Serena Di Vincenzo and Stefania Gerbino and Liboria Siena and Mark Gjomarkaj and Elisabetta Pace},
  journal={Biochimica et biophysica acta},
  year={2014},
  volume={1840 7},
  pages={2299-309}
}
BACKGROUND 17-Oxo-DHA is an endogenous electrophilic derivative of the omega-3 fatty acid docosahexaenoic acid (DHA) which is generated in activated macrophages by the action of cyclooxygenase-2. METHODS The ability of 17-oxo-DHA to control inflammation and oxidative stress was tested in human macrophages (THP-1) and bronchial epithelial cell line (16HBE) stimulated with cigarette smoke extract (CSE) and lipopolysaccharide (LPS). All data were further confirmed using primary bronchial… CONTINUE READING

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