Dual actions of vanadate on high K-induced contraction in guinea-pig taenia coli.

Effects of vanadate (NH4VO3: VAN) on tension development, membrane potential and cellular Na content were investigated in guinea-pig taenia coli depolarized by 62.7 mM KCl solution. VAN (10(-4) - 10(-3) M) caused a transient increase in the K developed tension followed by a relaxation. The VAN-induced contraction was observed even in a low Ca (0.13 mM… CONTINUE READING