Dual actions of nitric oxide on angiogenesis: possible roles of PKC, ERK, and AP-1.

@article{Jones2004DualAO,
  title={Dual actions of nitric oxide on angiogenesis: possible roles of PKC, ERK, and AP-1.},
  author={Michael K. Jones and Kouji Tsugawa and Andrzej S. Tarnawski and Dolgor Baatar},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={318 2},
  pages={520-8}
}
Regulation of angiogenesis by nitric oxide (NO) is controversial since NO has been shown to have both pro- and anti-angiogenic effects. In this study, we examined the effect of the NO donor, S-nitro-N-acetyl-penicillamine (SNAP), on in vitro angiogenesis, and the mechanisms involved: PKC activity, ERK and c-Jun phosphorylation, and AP-1 DNA binding activity, in microvascular endothelial cells. SNAP, at 0.5-4 mM, significantly and dose-dependently inhibited angiogenesis, PKC activity, and ERK… CONTINUE READING

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