Dual actions involved in arsenite-induced oxidative DNA damage.

  title={Dual actions involved in arsenite-induced oxidative DNA damage.},
  author={Xu-Jun Qin and Laurie G. Hudson and Wenlan Liu and Wei Ding and Karen L. Cooper and Ke Jian Liu},
  journal={Chemical research in toxicology},
  volume={21 9},
Arsenic is a recognized human carcinogen, but the mechanism of carcinogenesis is not well understood. Oxidative stress and inhibition of DNA damage repair have been postulated as potential carcinogenic actions of arsenic. The present study tests the hypothesis that arsenite not only induces oxidative stress but also inhibits the activity of the DNA base excision repair protein, poly(ADP-ribose) polymerase-1 (PARP-1), leading to exacerbation of the oxidative DNA damage induced by arsenic. HaCat… CONTINUE READING