Dual action of ototoxic antibiotics on sensory hair cells

All aminoglycoside antibiotics in clinical use are ototoxic in that they can cause permanent malfunctioning of the cochlea and vestibule1–3. It is generally assumed that these ototoxic antibiotics primarily affect the sensory hair cells in the inner ear and that degeneration of secretory and neural elements comes later2–5. Most experimental work on… (More)