Dual action of nitric oxide in pathogenesis of indomethacin-induced small intestinal ulceration in rats.

@article{Tanaka1999DualAO,
  title={Dual action of nitric oxide in pathogenesis of indomethacin-induced small intestinal ulceration in rats.},
  author={Akiko Tanaka and Tomonori Kunikata and Hiroyuki Mizoguchi and Shinichi Kato and Koji Takeuchi},
  journal={Journal of physiology and pharmacology : an official journal of the Polish Physiological Society},
  year={1999},
  volume={50 3},
  pages={405-17}
}
We investigated the pathogenic role of nitric oxide (NO) in indomethacin-induced intestinal ulceration in rats. Nonfasting animals responded to a single administration of indomethacin (10 mg/kg, s.c.), resulting in multiple hemorrhagic lesions in the small intestine, mostly the jejunum and ileum. The damage was first observed 6 hr after indomethacin, the severity increasing progressively with time up to 24 hr later, accompanied with the gene expression of inducible NO synthase (iNOS) and the… CONTINUE READING