Dual action of isoprenols from herbal medicines on both PPARgamma and PPARalpha in 3T3-L1 adipocytes and HepG2 hepatocytes.

@article{Takahashi2002DualAO,
  title={Dual action of isoprenols from herbal medicines on both PPARgamma and PPARalpha in 3T3-L1 adipocytes and HepG2 hepatocytes.},
  author={Nobuyuki Takahashi and Teruo Kawada and Tsuyoshi Goto and Takayuki Yamamoto and Aki Taimatsu and N Matsui and Kazuhiro Kimura and Masayuki Saito and Masashi Hosokawa and Kazuo Miyashita and Tohru Fushiki},
  journal={FEBS letters},
  year={2002},
  volume={514 2-3},
  pages={315-22}
}
Several herbal medicines improve hyperlipidemia, diabetes and cardiovascular diseases. However, the molecular mechanism underlying this improvement has not yet been clarified. In this study, we found that several isoprenols, common components of herbal plants, activate human peroxisome proliferator-activated receptors (PPARs) as determined using the novel GAL4 ligand-binding domain chimera assay system with coactivator coexpression. Farnesol and geranylgeraniol that are typical isoprenols in… CONTINUE READING

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