Dual action of TGF-beta1 on nasal-polyp derived fibroblasts.

  title={Dual action of TGF-beta1 on nasal-polyp derived fibroblasts.},
  author={Stewart C Little and S Brandon Early and Charles Ryan Woodard and David C. Shonka and Joseph K. Han and Larry Borish and John W. Steinke},
  journal={The Laryngoscope},
  volume={118 2},
OBJECTIVES Transforming growth factor beta-1 (TGF-beta1) is a known fibrogenic factor with immunosuppressive properties. We wanted to determine the effect of stimulation with TGF-beta1 on nasal polyp-derived fibroblasts and assess the role this molecule would have in polyp formation and growth. STUDY DESIGN Nasal-polyp derived fibroblasts were cultured with or without TGF-beta1, and proliferation and cytokine secretion were measured. METHODS Fibroblasts were isolated from nasal polyps… CONTINUE READING


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