Dual action antimicrobials: nitric oxide release from quaternary ammonium-functionalized silica nanoparticles.

@article{Carpenter2012DualAA,
  title={Dual action antimicrobials: nitric oxide release from quaternary ammonium-functionalized silica nanoparticles.},
  author={Alexis Wells Carpenter and Brittany Virginia Worley and Danielle L Slomberg and Mark H Schoenfisch},
  journal={Biomacromolecules},
  year={2012},
  volume={13 10},
  pages={3334-42}
}
The synthesis of quaternary ammonium (QA)-functionalized silica nanoparticles with and without nitric oxide (NO) release capabilities is described. Glycidyltrialkylammonium chlorides of varied alkyl chain lengths (i.e., methyl, butyl, octyl, and dodecyl) were tethered to the surface of amine-containing silica nanoparticles via a ring-opening reaction. Secondary amines throughout the particle were then functionalized with N-diazeniumdiolate NO donors to yield dual functional nanomaterials with… CONTINUE READING