Dual-acting stapled peptides target both HIV-1 entry and assembly

  title={Dual-acting stapled peptides target both HIV-1 entry and assembly},
  author={Hongtao Zhang and Francesca Curreli and Abdul Rais Abdul Waheed and Peter Y Mercredi and Mansi Mehta and Pallavi Bhargava and Daniel Scacalossi and Xiaohe Tong and Shawn Lee and Alan H Cooper and Michael F Summers and Eric O. Freed and Asim Kumar Debnath},
Previously, we reported the conversion of the 12-mer linear and cell-impermeable peptide CAI to a cell-penetrating peptide NYAD-1 by using an i,i + 4 hydrocarbon stapling technique and confirmed its binding to the C-terminal domain (CTD) of the HIV-1 capsid (CA) protein with an improved affinity (Kd ~ 1 μM) compared to CAI (Kd ~ 15 μM). NYAD-1 disrupts the formation of both immature- and mature-like virus particles in in vitro and cell-based assembly assays. In addition, it displays potent anti… CONTINUE READING
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Antiviral activity of alpha-helical stapled peptides designed from the HIV-1 capsid dimerization

  • H Zhang, F Curreli, X Zhang, S Bhattacharya, AA Waheed, A Cooper
  • Retrovirology
  • 2011
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