Dual Targeting of Tumor Cells with Bispecific Single-Chain Fv-Immunoliposomes

@inproceedings{Mack2012DualTO,
  title={Dual Targeting of Tumor Cells with Bispecific Single-Chain Fv-Immunoliposomes},
  author={Katharina Mack and Ronny R{\"u}ger and Sina Fellermeier and Oliver Seifert and Roland E Kontermann},
  year={2012}
}
Antibody fragments, especially single-chain Fv fragments, have been established for the generation of immunoliposomes for targeted drug delivery in cancer therapy and other applications. Bispecific immunoliposomes should be useful for dual targeting addressing interand intratumoral heterogeneity of tumor antigen expression. Here, we established a protocol to generate dual-targeted immunoliposomes using genetically engineered scFv molecules recognizing two different tumor-associated antigens… CONTINUE READING
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