Dual Targeting of Tissue Factor and CD105 for Preclinical PET Imaging of Pancreatic Cancer.

@article{Luo2016DualTO,
  title={Dual Targeting of Tissue Factor and CD105 for Preclinical PET Imaging of Pancreatic Cancer.},
  author={Haiming Luo and Christopher G. England and Sixiang Shi and Stephen A. Graves and R. G. Najera Hernandez and Bai Fen Liu and Charles P. Theuer and Hing Choi Wong and Robert Jerry Nickles and Weibo Cai},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2016},
  volume={22 15},
  pages={
          3821-30
        }
}
PURPOSE Pancreatic adenocarcinoma is a highly aggressive cancer, currently treated with limited success and dismal outcomes. New diagnostic and treatment strategies offer the potential to reduce cancer mortality. Developing highly specific noninvasive imaging probes for pancreatic cancer is essential to improving diagnostic accuracy and monitoring therapeutic intervention. EXPERIMENTAL DESIGN A bispecific heterodimer was synthesized by conjugating an anti-tissue factor (TF) Fab with an anti… CONTINUE READING
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