Dual-Targeting Magnetic PLGA Nanoparticles for Codelivery of Paclitaxel and Curcumin for Brain Tumor Therapy.

@article{Cui2016DualTargetingMP,
  title={Dual-Targeting Magnetic PLGA Nanoparticles for Codelivery of Paclitaxel and Curcumin for Brain Tumor Therapy.},
  author={Yanna Cui and Meng Zhang and Feng Zeng and Hongyue Jin and Qin Xu and Yongzhuo Huang},
  journal={ACS applied materials & interfaces},
  year={2016},
  volume={8 47},
  pages={
          32159-32169
        }
}
Chemotherapy is one of the most important strategies for glioma treatment. However, the "impermeability" of the blood-brain barrier (BBB) impedes most chemotherapeutics from entering the brain, thereby rendering very few drugs suitable for glioma therapy, letting alone application of a combination of chemotherapeutics. Thereby, there is a pressing need to overcome the obstacles. A dual-targeting strategy was developed by a combination of magnetic guidance and transferrin receptor-binding… CONTINUE READING

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