Dual-Specificity Phosphatase 1 and Tristetraprolin Cooperate To Regulate Macrophage Responses to Lipopolysaccharide

@inproceedings{Smallie2015DualSpecificityP1,
  title={Dual-Specificity Phosphatase 1 and Tristetraprolin Cooperate To Regulate Macrophage Responses to Lipopolysaccharide},
  author={Tim Smallie and Ewan Ross and Alaina J Ammit and Helen Elizabeth Cunliffe and Tina Yue Tang and Dalya Rivka Rosner and Michael Luke Ridley and Christopher D Buckley and Jeremy Saklatvala and Jonathan L. E. Dean and A R Clark},
  booktitle={Journal of immunology},
  year={2015}
}
Dual-specificity phosphatase (DUSP) 1 dephosphorylates and inactivates members of the MAPK superfamily, in particular, JNKs, p38α, and p38β MAPKs. It functions as an essential negative regulator of innate immune responses, hence disruption of the Dusp1 gene renders mice extremely sensitive to a wide variety of experimental inflammatory challenges. The principal mechanisms behind the overexpression of inflammatory mediators by Dusp1(-/-) cells are not known. In this study, we use a genetic… CONTINUE READING

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