Dual Roles of IL-15 in Cancer Biology

  title={Dual Roles of IL-15 in Cancer Biology},
  author={Marina Fabbi and Silvano Ferrini},
IL-15 is an immune-enhancing cytokine belonging to the IL-2 family, which supports survival, proliferation and functional activities of NK, NK-T, T and B cells. Moreover, IL-15 may support the growth and survival of different lymphoid malignancies, suggesting that targeting of the IL-15/IL-15R system or its downstream signaling cascade may result in therapeutic effects, in these tumors. On the other hand, given its immune-enhancing activities IL-15 has been considered a good candidate for… 

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